Endocrine Abstracts

Introduction: Hypopituitary patients with GHD tend to have a reduced exercise capacity. GH is secreted during exercise, has a strong lipolytic action and has been shown to be positively correlated with exercise performance. We hypothesized that the lack of GH leads to a reduced systemic availability of free fatty acids (FFA) during exercise thereby affecting exercise performance.Methods: Patients with GHD and matched sedentary control subjects (CS) were ...

Introduction: Current treatment guidelines for patients with insufficiency of the hypothalamic pituitary adrenal (HPA) axis recommend weight adjusted glucocorticoid supplementation doses to minimize risk of negative side effects (e.g. osteoporosis etc).However, little is known on a potential dose-dependent effect of glucocorticoid supplementation on overall mortality in patients with pituitary disease. Non-functioning pituitary adenoma (NFPA) is one of t...

Introduction: Increased levels of ectopic lipids (IMCL and IHCL) have been related to insulin resistance. Aerobic exercise affects IMCL. GHRT is known to increase exercise capacity, insulin resistance and decrease fat mass. The effect of GHRT on ectopic lipids is not known.Methods: Ten patients with GHD and ten sedentary control subjects (CS; matched for gender, age, BMI and waist) were recruited. VO2max was assessed using an exercise test on ...